Project Description: The overall objective in this proposal is to use the natural variation that occurs in a panel of wild-caught fly lines to characterize the GRN responsible for precise anterior-posterior (AP) patterning the early Drosophila embryo. This will test the central hypothesis that gene expression patterns in the AP patterning system have undiscovered regulation that can be found by examining the correlation between gene expression and natural variation in the genomes of these flies. Our lab is characterizing the dynamics of the GAP Gene transcriptional network responsible for AP patterning. These efforts include the development of computer vision approaches for feature extraction and non-linear systems modeling and analysis.
Contributors: Dr. Samiul Haque, Sharva Hiremath.